[{"@context":"https://schema.org","@type":"JobPosting","title":"Senior Scientist II, Pharmaceutical Development – Thermodynamics & AI/ML Applications (all genders) (fulltime, regular)","description":"

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas – immunology, oncology, neuroscience, and eye care – and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on X, Facebook, Instagram, YouTube, LinkedIn and Tik Tok.

Job Description

People. Passion. Possibilities. Three words that make a world of difference.

More than a job. It's a chance to make a real difference.

Welcome to AbbVie! As part of an international company with 48,000 employees worldwide and around 3,000 employees in Germany, you will have the opportunity of addressing some of tomorrows unmet medical needs in close collaboration with your colleagues. Are you passionate about improving global health care? Do you want to contribute to improving patients' quality of life through your expertise? In a challenging work environment that offers opportunities of developing and increasing your own skills? Youve come to the right place!

Together, we break through – as Senior Scientist II, Pharmaceutical Development – Thermodynamics & AI/ML Applications (all genders)

In this role you'll contribute to the design and application of thermodynamics-based and AI/ML-enabled solutions that support pharmaceutical formulation and process development. The role is responsible for translating complex physicochemical and process data into predictive insight, with emphasis on solubility, phase behavior, physical stability, and material interactions relevant to robust product and process design.

Working in a multidisciplinary environment, you`ll develop and apply hybrid modeling approaches that combine first-principles understanding with machine learning methods, ensuring models are scientifically grounded, fit for purpose, and operationally useful. You`ll also develop (in-silico) digital tools and decision-support workflows that enable broader adoption of modeling outputs across development teams.

Make your mark:

Develop and apply predictive models to guide formulation and process development decisions across pharmaceutical programs.
Apply thermodynamic and quantum mechanical principles to predict key material and product behaviors such as solubility, phase behavior, crystallization, supersaturation, and moisture sensitivity.
Build and improve models for physical stability, material compatibility, excipient interactions, and process-related performance of drug substances and drug products.
Create and implement practical tools and workflows using hybrid physics-based and machine learning approaches that integrate mechanistic insight with experimental and historical data.
Define and execute robust model validation strategies, including uncertainty assessment, applicability domain evaluation, and clear performance documentation.
Convert complex datasets into actionable insights for formulation selection, risk assessments, experiment prioritization, and overall development strategy.
Communicate model findings, assumptions, limitations, and recommendations clearly to both technical and non-technical stakeholders while supporting modeling best practices and reproducibility.
Work closely with thermodynamic modeling experts, internal modeling teams, and laboratory scientists to ensure model development addresses real-world development needs.

This is how you make a difference:

Advanced degree (PhD) in pharmaceutical sciences, chemical engineering, physical chemistry, materials science, data science for physical systems or related disciplines.
Strong understanding of thermodynamics and its application to pharmaceutical materials, formulations, and process performance.
Proven ability to perform quantitative modeling and analyze and interpret physicochemical experimental data.
Experience using AI/ML for scientific or engineering problems, with focus on data quality, model suitability, and interpretability.
Ability to combine mechanistic insight with data-driven methods to address real-world development challenges.
Proficiency in structuring analyses, documenting methods, and presenting conclusions in a business-relevant manner.
Strong collaboration and professional communication skills for working across cross-functional, technical, and international teams.
Excellent written and verbal communication skills in English

What we offer you:

with a diverse work environment where you can have a real impact
with an open corporate culture
with an attractive salary
with an intensive onboarding process with a mentor at your side
with flexible work models for a healthy work-life balance
with a corporate health management that offers comprehensive health and exercise programs
with company social benefits
with a wide range of career opportunities in an international organization
with top-tier, attractive development opportunities
with a strong international network

At multiple times, we have been globally recognized as a \"Great Place to Work\" and we are proud to provide our employees with the flexibility to maintain a healthy work-life balance. We take our impact on the environment and our communities seriously and therefore focus on giving something back on a regular basis. We are committed to equality, equity, diversity and inclusion (EED&I) – a commitment that is fundamental to us. This includes appreciating different perspectives, creating an inclusive culture and treating all employees with dignity and respect.

At AbbVie, your individual contributions count – help us move mountains together. Be a part of our success, grow with us and accomplish more than you could have imagined. Sounds like the perfect career opportunity for you? We look forward to receiving your application! All you need is a complete CV – we will discuss everything else with you in person.

Any questions? Feel free to email Talentacquisition.de@abbvie.com – We look forward to hearing from you!

AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community.  Equal Opportunity Employer/Veterans/Disabled.

US & Puerto Rico only - to learn more, visit https://www.abbvie.com/join-us/equal-employment-opportunity-employer.html

US & Puerto Rico applicants seeking a reasonable accommodation, click here to learn more:

https://www.abbvie.com/join-us/reasonable-accommodations.html

About AbbVie

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas including immunology, oncology and neuroscience - and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on LinkedIn, Facebook, Instagram, X and YouTube.

","datePosted":"2026-08-04T14:15:01.399Z","validThrough":"2026-09-03T14:15:01.399Z","employmentType":"FULL_TIME","hiringOrganization":{"@type":"Organization","name":"Abbvie"},"jobLocation":{"@type":"Place","address":{"@type":"PostalAddress","addressLocality":"Ludwigshafen","addressCountry":"DE"}},"identifier":{"@type":"PropertyValue","name":"Abbvie","value":"smartrecruiters_abbvie_3743990014425635"},"directApply":false,"url":"https://jobs.smartrecruiters.com/abbvie/3743990014425635"},{"@context":"https://schema.org","@type":"JobPosting","title":"Validation Manager (all genders) | Fixed-term contract for 2 years | Full-time","description":"

At our Ludwigshafen site, the Validation Manager plays a key role in the introduction of new manufacturing processes and the optimization of existing ones. The role has a particular focus on melt extrusion, secondary packaging, and the assembly of autoinjectors across the full product lifecycle, including development, validation, and manufacturing in a cGMP environment.
\n
\nWith your experience and passion, you will work closely with a cross-functional matrix team to support technology transfers and be responsible for introducing new products into production through to validation. You will also contribute to the development and optimization of processes and procedures for the manufacture and packaging of solid dosage forms, combination products, and medical devices.
\n
\nMain Responsibilities

Support the introduction of new products through to validation.
Track and trend product and process data, perform statistical evaluation of data, and derive appropriate actions.
Independently prepare the annual validation master plan, including timelines, as well as templates for validation plans and reports.
Ensure compliance with internal requirements, cGMP, and current regulatory expectations, and support the implementation of these requirements within TechOps.
Present validation concepts and validation activities during regulatory inspections and internal audits, and represent the site in the CoE (Center of Excellence).
Independently lead investigations of potential deviations with impact on product quality.
Independently execute technical trials and update manufacturing and work instructions as needed.
Support and prepare the annual Product Quality Report for all existing and future products.

University degree (Master’s, Diploma) in Chemistry, Biochemistry, Pharmacy, or a similar scientific discipline.
Minimum 3 years of experience in the pharmaceutical industry, especially in secondary and primary packaging or the manufacture of solid dosage forms.
Experience in cGMP and validation environments in accordance with Annex 15, EU GMP Guide, and 21 CFR 210/211.
Strong experience in troubleshooting, process optimization, and scale-up of manufacturing processes.
Very good knowledge of the manufacture, packaging, testing, and evaluation of pharmaceutical dosage forms.
Excellent English language skills.
High level of initiative, self-motivation, and flexibility.
Strong leadership, communication, and teamwork skills, including in an international environment.

What we offer you

A varied role where you can truly make a difference.
An open corporate culture.
Attractive compensation.
Comprehensive onboarding supported by a mentor.
Flexible working models for a healthy work-life balance.
Corporate health management with extensive health and sports programs.
Company benefits.
Diverse career options within an international company.
Attractive, high-level professional development opportunities.
A strong international network.

\nAt AbbVie, you will find a workplace where your individual contribution counts, enabling us to achieve great things together.
\n
\nJoin us and grow—and constantly surpass your own expectations!
\n

US & Puerto Rico only - to learn more, visit https://www.abbvie.com/join-us/equal-employment-opportunity-employer.html

US & Puerto Rico applicants seeking a reasonable accommodation, click here to learn more:

https://www.abbvie.com/join-us/reasonable-accommodations.html

About AbbVie

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas including immunology, oncology and neuroscience - and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on LinkedIn, Facebook, Instagram, X and YouTube.

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English-Speaking Jobs in Ludwigshafen

Job listings

Senior Scientist II, Pharmaceutical Development – Thermodynamics & AI/ML Applications (fulltime, regular)

Validation Manager | Fixed-term contract for 2 years | Full-time